Signaling Pathway from G-Protein Families
| PAG Title | Signaling Pathway from G-Protein Families |
| PAG ID | WIG000336 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behaviour; in many cases this includes the regulation of gene transcription. Dotted line shows a more indirect pathway. |
| Species | Homo sapiens |
| nCoCo Score | 1,852 |
| Base PAG ID | WIG000336 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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